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AI-Edigene® EGFR p.E746_A750delELREA Reference Standard Plus

CBP10418

询价

索取COA

产品描述

产品数据库

Introduction
Format	Genomic DNA
Description	EGFR E746_A750del results in the deletion of five amino acids in the kinase domain of the Egfr protein from amino acids 746 to 750 (PMID: 17318210). E746_A750del results in increased Egfr kinase activity, activation of p44/42 MAPK and AKT in cell culture, promotes tumor growth in xenograft models (PMID: 16373402, PMID: 16912195), and is transforming in cell culture (PMID: 29533785).

Technical Data
DNA Change	c.2236_2250del15 GAATTAAGAGAAGCA>-
AA Change	p.E746_A750delELREA
Mutation type	Deletion - In frame
Zygosity	Homozygous
Allelic Frequency	100%
Transcript	ENST00000275493
Cosmic ID	COSM6225
Chr position(GRCh37)	chr7:55242466_55242480
Buffer	Tris-EDTA

Product Information
Intended Use	Research Use Only
Unit Size	1ug
Concentration	Download for COA
Purofication	Download for COA
DNA electrophoresis	Download for COA
Sanger sequencing
Storage	2-8℃
Expiry	36 months from the date of manufacture

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