TP53 p.P72R (rs1042522-C/G) Reference Standard

CBP10633

询价

索取COA

产品描述

产品数据库

Introduction
Format	Genomic DNA
Description	TP53 P72R lies within the CCAR2, HRMT1L2, and WWOX-interacting regions of the Tp53 protein (UniProt.org). P72R is a common polymorphism that decreases Pgc-1a binding, increases mitochondrial function, migration, invasion, and tumor cell metastasis induced by mutant Tp53 in cell culture and in mouse models, but transactivates downstream target genes and inhibits cell growth similar to wild-type Tp53 in culture, and therefore, its effect on Tp53 protein function is unknown.

Technical Data
DNA Change:	c.215C>G
AA Change	p.P72R
Mutation type	Substitution - Missense
Zygosity	Heterozygous
Allelic Frequency	50%
Transcript	NM_000546.6
Cosmic ID	COSM250061
Chr position(GRCh38)	chr17-7676154-G-C
Buffer:	Tris-EDTA

Product Information
Intended Use	Research Use Only
Unit Size	1ug
Concentration	Download for COA
Purity	Download for COA
DNA electrophoresis	Download for COA
Sanger sequencing
Storage	2-8°C
Expiry	36 months from the date of manufacture

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