TP53 p.R175H Reference Standard

CBP10143

询价

索取COA

产品描述

产品数据库

Introduction
Format	Genomic DNA
Description	TP53 R175H is a hotspot mutation that lies within the DNA binding domain of the Tp53 protein (PMID: 22713868). R175H results in decreased activation of Tp53 targets and interferes with activation by wild-type Tp53, leads to resistance to apoptosis, decreased genomic stability, and promotes tumorigenesis, and additionally confers a gain of function to Tp53, resulting in aberrant activation of gene transcription and enhanced cell migration (PMID: 10713666, PMID: 22114072, PMID: 19881536, PMID: 14743206).

Technical Data
DNA Change:	c.524G>A
AA Change	p.R175H
Mutation type	Substitution - Missense
Zygosity	Homozygous
Allelic Frequency	100%
Transcript	ENST00000269305
Cosmic ID	COSM10648
Chr position(GRCh37)	chr17:7578406
Buffer:	Tris-EDTA

Product Information
Intended Use	Research Use Only
Unit Size	1ug
Concentration	Download for COA
Purofication	Download for COA
DNA electrophoresis	Download for COA
Sanger sequencing
Storage	2-8℃
Expiry	36 months from the date of manufacture

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