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309 Gene Plus TMB Panel

CBPF0002

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309 Gene Plus TMB Panel
Descripition 此实体瘤泛癌种Panel包含下列309个基因的全部编码区,5个常见实体瘤的融合基因热点内含子区域,99个微卫星不稳定检测位点,覆盖基因组约0.86Mb区域,支持包括碱基替换、插入、缺失检测分析。
 
309个基因:含全部外显子区域
ABL1 CBFB DNMT3A GABRA6 SMO MAP2K2 CEBPA RAD52 INPP4B
C11ORF30 DAXX FLT1 KIT AURKA NOTCH3 FANCC TEK MKNK1
CUL3 FGFR3 KDM6A MYD88 CDK12 PTPN11 HNF1A BRCA2 PBRM1
FGF4 JAK3 MUTYH POLE ERBB3 SPEN MCL1 CRKL RBM10
IRF4 MSH6 PIK3R1 SMAD2 GNA11 BARD1 NTRK2 FGF10 TNFRSF14
MPL PIK3C2B SDHD ZNF703 LTK CDKN1B RAD51 IDH2 BTK
PDCD1LG2 RPTOR WT1 ASXL1 NFKBIA ESR1 STK11 MEN1 CTNNB1
RET VEGFA AR CD79A PRKAR1A GSK3B BCOR PARP1 FGF3
TSC1 ALK CCNE1 EPHA3 SNCAIP MAP2K4 CHEK1 RAD54L IRF2
ACVR1B CBL DOT1L GATA3 AURKB NPM1 FANCG TET2 MLH1
CALR DDR1 FLT3 KLHL6 CDK4 PTPRO HRAS BRD4 PDCD1
CUL4A FGFR4 KDR NBN ERBB4 SPOP MDM2 CSF1R REL
FGF6 JUN MYC PPARG GNA13 BCL2 NTRK3 FGF12 TP53
IRS2 MST1R PIM1 SMAD4 LYN CDKN2A RAD51B IGF1R  
MRE11A PIK3C2G SETD2 ATM NKX2-1 EZH2 SUFU MERTK  
PDGFRA SDHA XPO1 CD79B PRKCI H3F3A BCORL1 PARP2  
RICTOR VHL ARAF EPHB1 SOCS1 MAP3K1 CHEK2 RAF1  
TSC2 ALOX12B CD22 GATA4 AXIN1 NRAS FANCL TGFBR2  
AKT1 CCND1 EED KMT2A CDK6 QKI HSD3B1 BRIP1  
CARD11 DDR2 FOXL2 NF1 ERCC4 SRC MDM4 CSF3R  
CXCR4 FH KEAP1 PPP2R1A GNAQ BCL2L1 P2RY8 FGF14  
FGFR1 KDM5A MYCL SMARCA4 MAF CDKN2B RAD51C IKBKE  
JAK1 MTAP PMS2 ATR NOTCH1 FAM46C SYK MET  
MSH2 PIK3CA SF3B1 CDC73 PTCH1 HDAC1 BRAF PARP3  
PDGFRB SDHB XRCC2 EPHB4 SOX2 MAP3K13 CIC RARA  
RNF43 WHSC1 ARFRP1 GATA6 AXL NT5C2 FAS TIPARP  
TYRO3 AMER1 CD274 KMT2D CDK8 RAC1 ID3 BTG1  
AKT2 CCND2 EGFR NF2 ERG STAG2 MED12 CTCF  
CASP8 DIS3 FUBP1 PPP2R2A GNAS BCL2L2 PALB2 FGF19  
CYP17A1 FLCN KEL SMARCB1 MAP2K1 CDKN2C RAD51D IKZF1  
FGFR2 KDM5C MYCN ATRX NOTCH2 FANCA TBX3 MITF  
JAK2 MTOR POLD1 CDH1 PTEN HGF BRCA1 PAX5  
MSH3 PIK3CB SGK1 ERBB2 SOX9 MAPK1 CREBBP RB1  
PDK1 SDHC ZNF217 GID4 BAP1 NTRK1 FBXW7 TNFAIP3  
ROS1 WHSC1L1 ARID1A KRAS CDKN1A RAD21 IDH1 BTG2  
U2AF1 APC CD70 NFE2L2 ERRFI1 STAT3 MEF2B CTNNA1  
AKT3 CCND3 EP300 PRDM1 GRM3 BCL6 PARK2 FGF23  
 
5个融合基因区域:部分内含子区域
NTRK1 intron9;10
ALK intron17;18;19;20;21
ROS1 intron33
RET intron11
FGFR3 intron14;16;17
 
99个微卫星不稳定位点
BAT26 2B3D NCI Panel(CSCO指南);Promega Panel
BAT25 2B3D NCI Panel(CSCO指南);Promega Panel
D5S346 2B3D NCI Panel(CSCO指南)
D2S123 2B3D NCI Panel(CSCO指南)
D17S250 2B3D NCI Panel(CSCO指南)
NR21 Promega Panel
NR24 Promega Panel
NR27 Promega Panel
MONO27 Promega Panel
MSI:10-99 额外已验证的89个微卫星位点
 
Product Information 
Intended Use Research Use Only
Unit Size 96 rxn
Storage -25 ~ -15°C
Expiry 12 months from the date of manufacture

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