hROR1/4T1
CBPG0072
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I. Background | |||
受体酪氨酸激酶样孤儿受体(Receptor Tyrosine Kinase-like orphan receptor,ROR)是 Ⅰ型受体酪氨酸激酶(receptor tyrosine kinase,RTK)家族中的成员,是一类膜受体,主要 包括 ROR1 和 ROR2。其中 ROR1 主要通过参与细胞内与细胞间信号传导,实现调节细胞 代谢、增殖、凋亡、分化、迁移、转移等功能。ROR1 在正常组织中(除了原肠胚时期) 表达量较低,但 ROR1 在多种肿瘤细胞高度表达,包括乳腺癌、卵巢癌、肾癌、肺腺细胞 癌、胃癌等实体瘤细胞以及某些血液肿瘤细胞。 | |||
II. Introduction | |||
Host Cell: | 4T1 | ||
Expressed gene: | hROR1 | ||
Stability: | 32 passages (in-house test, that not means the cell line will be instable beyond the passages we tested.) | ||
Freeze Medium: | 90% FBS+10% DMSO | ||
Culture Medium: | RPMI-1640+10%FBS+2ug/ml puromycin | ||
Mycoplasma Testing: | Negative | ||
Storage: | Liquid nitrogen | ||
III. Description of Host Cell Line | |||
Organism: | Mouse | ||
Tissue: | Mammary gland | ||
Morphology: | Epithelial | ||
Growth Properties: | Adherent | ||
IV. Representative Data | |||
Figure 1. Recombinant hROR1/4T1 stably expressing ROR1. |
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