FLT3-ITD [Y842C]/BaF3
CBP73100
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| I. Introduction | |
| Cell Line Name： | FLT3-ITD [Y842C]/BaF3 |
| Host Cell: | Ba/F3 |
| Stability: | 16 passages (in-house test, that not means the cell line will be instable beyond the passages we tested.) |
| Application: | Useful for the study of enzyme kinetics, screening inhibitors, and selectivity profiling. |
| Freeze Medium: | 90% FBS+10% DMSO |
| Complete Culture Medium: | RPMI-1640+10%FBS |
| Mycoplasma Status: | Negative |
| II. Background | |
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FLT3, receptor-type tyrosine-protein kinase FLT3, activates Akt, Ras, and Erk pathways to regulate differentiation, proliferation, and survival of hematopoietic progenitor cells (PMID: 29316714, PMID: 28538663). Activating mutations of FLT3 are common in hematologic tumors (PMID: 19467916) and the internal tandem duplication (ITD) mutation is commonly observed in acute myeloid leukemia (PMID: 30181385). |
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| III. Representative Data | |
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1.FLT3-ITD [Y842C]/BaF3
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2. Anti-proliferation assay |
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Figure 2. Anti-proliferation assay of two reference compounds on the FLT3-ITD [Y842C]/BaF3 Stable Cell Line. |
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