KRAS G12C-A59T/BaF3
CBP73380
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| I. Introduction | |
| Cell Line Name： | KRAS G12C-A59T/BaF3 |
| Host Cell: | Ba/F3 |
| Stability: | 16 passages (in-house test, that not means the cell line will be instable beyond the passages we tested.) |
| Application: | Useful for the study of enzyme kinetics, screening inhibitors, and selectivity profiling. |
| Freeze Medium: | 90% FBS+10% DMSO |
| Complete Culture Medium: | RPMI-1640+10%FBS+2ug/ml puromycin |
| Mycoplasma Status: | Negative |
| II. Background | |
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KRAS, KRAS proto-oncogene, GTPase, is a member of the small GTPase superfamily and a key regulator of the MAPK, PI3K/AKT/mTOR pathways (PMID: 23622131). KRAS mutations are identified in a wide range of cancers (PMID: 28666118). |
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| III. Representative Data | |
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1. Sanger of KRAS G12C-A59T/BaF3
Figure 1. KRAS G12C-A59T/BaF3 G12C
Figure 2. KRAS G12C-A59T/BaF3 A59T |
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2. Anti-proliferation assay
Figure 3. CTG Proliferation Assay of KRAS G12C/A59T BaF3 Cells (C13). |
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