hDLL3/4T1
CBPG0122
询 价
留 言
产品描述
产品数据库
I. Background | |||
DLL3 基因别名 SCDO1,其编码的蛋白 DLL3 是一种跨膜蛋白,是 Notch 受体配体 Delta/Serrate/lag2(DSL)组的成员,在胚层的分离中,影响着体细胞边界的形成。 DLL3 基因突变会导致严重的体节发生异常和脊椎肋骨发育不全。DLL3 是一种高度肿瘤选 择性的细胞表面靶点,在正常肺癌组织及癌旁组织中不表达。DLL3 在多种肿瘤中表达上 调,在小细胞肺癌、乳腺癌、垂体瘤、急性髓系白血病中有促癌作用,但在肝癌 、神经胶 质瘤和恶性胶质瘤中却发挥了抑癌作用。 | |||
II. Introduction | |||
Host Cell: | 4T1 | ||
Expressed gene: | hDLL3 | ||
Stability: | 32 passages (in-house test, that not means the cell line will be instable beyond the passages we tested.) | ||
Freeze Medium: | 90% FBS+10% DMSO | ||
Culture Medium: | RPMI-1640+10%FBS+2 μg/ml puromycin | ||
Mycoplasma Testing: | Negative | ||
Storage: | Liquid nitrogen | ||
III. Description of Host Cell Line | |||
Organism: | Mouse | ||
Tissue: | Mammary gland | ||
Morphology: | Epithelial | ||
Growth Properties: | Adherent | ||
IV. Representative Data Figure 1. Recombinant hDLL3/4T1 stably expressing hDLL3. |
|||
|
|||